Adequan I.M. Multi-Dose, 100mg/ml, 50 ml

Polysulfated Glycoaminoglycan Sterile Injection

Adequan I.M. – Luitpold Pharmaceuticals is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. It stimulates the natural joint repair process within 2 hours of the first injection.

Adequan I.M. inhibits harmful enzymes that attack the synovial fluid and cartilage while stimulating cartilage repair. The health of the cartilage is critical to the performance of the joint. Adequan i.m is complete FDA- approved one-horse treatment regimen per package of 7 vials. Also available in a multi-dose 50 ml vial.

Adequan I.M. Description:

Each 5 milliliters of Adequan i.m. contains 500 mg of Polysulfated Glycosaminoglycan and Water for Injection q.s. Sodium Hydroxide and/or Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity. Improves carpal flexion by 71%. Improves synovial fluid protein by 83%.

Adequan I.M. Pharmacology:

Polysulfated Glycosaminoglycan is chemically similar to the glycosaminoglycans in articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor and diminishes or reverses the pathologic recesses of traumatic or degenerative joint disease which result in a net loss of cartilage matrix components. PSGAG improves joint function by reducing synovial fluid protein levels and increasing synovial fluid Hyaluronic acid concentration in traumatized equine carpal and hock joints.

Adequan I.M. Toxicity:

Toxicity studies were conducted in horses. Doses as high as 2,500 mg were administered intramuscularly to 6 horses twice a week for 12 weeks. This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen. Clinical observations revealed no o redness or swelling at the injection site or in the affected joint. No animal had any clinical or laboratory evidence of toxicity.

Adequan I.M. Contraindications:

There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.

Adequan I.M. Warning:

Not for use in horses intended for food.

Dosage and Administration:

The recommended dose of Adequan i.m. in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan i.m. with other drugs or solvents.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Reproductive Safety:

Studies have not been conducted to establish safety in breeding horses.

Dispose of spent needles in accordance with all federal, state and local environmental laws.

Adequan I.M.Warning:

Keep this and all medications out of the reach of children.

How Adequan I.M. is Supplied:

Adequan i.m. solution, 500 mg/5 mL is available in 5 mL glass vials, packaged in boxes of 7 ,and Multi-Dose 50 ml vial

Adequan I.M. Storage Conditions:

Store at controlled room temperature 18°-25°C (64°-77°F). Discard unused portion.

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